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Neurology. 2013 Nov 5;81(19):1650-1. doi: 10.1212/01.wnl.0000435303.10519.15. Epub 2013 Oct 4.

A physiologic biomarker for cerebral amyloid angiopathy.

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From the Department of Neurology, Massachusetts General Hospital, Boston.


Cerebral amyloid angiopathy (CAA), a common small-vessel disease of older adults characterized by accumulation of amyloid-β in leptomeningeal and cortical blood vessels, is a well-established cause of intracerebral hemorrhage.(1) Recent years have seen the emergence of clinical research reports establishing associations between CAA, ischemic brain injury, and vascular cognitive impairment (VCI). CAA patients had a higher load of chronic microvascular white matter hyperintensities (WMH), small infarcts, as well as a high degree of WMH progression.(2,3) A more recent report showed that vascular amyloid load strongly correlated with ischemic WMH in CAA.(4.)

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