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Nat Methods. 2013 Dec;10(12):1211-2. doi: 10.1038/nmeth.2646. Epub 2013 Oct 6.

pLogo: a probabilistic approach to visualizing sequence motifs.

Author information

1
1] Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA. [2].

Abstract

Methods for visualizing protein or nucleic acid motifs have traditionally relied upon residue frequencies to graphically scale character heights. We describe the pLogo, a motif visualization in which residue heights are scaled relative to their statistical significance. A pLogo generation tool is publicly available at http://plogo.uconn.edu/ and supports real-time conditional probability calculations and visualizations.

PMID:
24097270
DOI:
10.1038/nmeth.2646
[Indexed for MEDLINE]

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