Format

Send to

Choose Destination
Exp Physiol. 2014 Jan;99(1):35-51. doi: 10.1113/expphysiol.2013.071969. Epub 2013 Oct 4.

Structure and function of voltage-gated sodium channels at atomic resolution.

Author information

1
W. A. Catterall: Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195-7280, USA. wcatt@u.washington.edu.

Abstract

Voltage-gated sodium channels initiate action potentials in nerve, muscle and other excitable cells. Early physiological studies described sodium selectivity, voltage-dependent activation and fast inactivation, and developed conceptual models for sodium channel function. This review article follows the topics of my 2013 Sharpey-Schafer Prize Lecture and gives an overview of research using a combination of biochemical, molecular biological, physiological and structural biological approaches that have elucidated the structure and function of sodium channels at the atomic level. Structural models for voltage-dependent activation, sodium selectivity and conductance, drug block and both fast and slow inactivation are discussed. A perspective for the future envisions new advances in understanding the structural basis for sodium channel function and the opportunity for structure-based discovery of novel therapeutics.

PMID:
24097157
PMCID:
PMC3885250
DOI:
10.1113/expphysiol.2013.071969
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center