Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Struct Mol Biol. 2013 Nov;20(11):1325-32. doi: 10.1038/nsmb.2678. Epub 2013 Oct 6.

Analysis of microRNA-target interactions across diverse cancer types.

Author information

1
Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Abstract

Little is known about the extent to which individual microRNAs (miRNAs) regulate common processes of tumor biology across diverse cancer types. Using molecular profiles of >3,000 tumors from 11 human cancer types in The Cancer Genome Atlas, we systematically analyzed expression of miRNAs and mRNAs across cancer types to infer recurrent cancer-associated miRNA-target relationships. As we expected, the inferred relationships were consistent with sequence-based predictions and published data from miRNA perturbation experiments. Notably, miRNAs with recurrent target relationships were frequently regulated by genetic and epigenetic alterations across the studied cancer types. We also identify new examples of miRNAs that coordinately regulate cancer pathways, including the miR-29 family, which recurrently regulates active DNA demethylation pathway members TET1 and TDG. The online resource http://cancerminer.org allows exploration and prioritization of miRNA-target interactions that potentially regulate tumorigenesis.

PMID:
24096364
PMCID:
PMC3982325
DOI:
10.1038/nsmb.2678
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center