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J Hypertens. 2013 Nov;31(11):2230-6; discussion 2236. doi: 10.1097/HJH.0b013e328364bcbf.

Prevalence and factors related to urinary albumin excretion in obese youths.

Author information

1
aPediatric Department, Consorcio Hospital General, University of Valencia, Valencia bCIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III, Madrid cInternal Medicine, Hospital Clinico, INCLIVA, University of Valencia, Valencia, Spain.

Abstract

OBJECTIVES:

The aim of the present study is to assess whether obesity is associated with urinary albumin excretion and what the main determinants are.

METHODS:

One hundred and thirty-four obese white children and adolescents of both sexes, ranging from 9 to 18 years of age (mean age 12.6 ± 2.0), were included in the study. Obesity was defined on the basis of a threshold BMI z-score of more than 2 (Cole's LMS method) and overweight with a BMI from the 85th to 95th percentile. Office blood pressure was measured using a mercury sphygmomanometer. Urinary albumin excretion was measured in the first voiding urine of the morning and expressed in albumin/creatinine ratio in mg/g. Reproducibility of the urinary albumin excretion was studied by the Bland and Altman technique in a subgroup. Triglycerides, uric acid, fasting glucose and insulin were measured and the homeostatic model assessment (HOMA) index was calculated.

RESULTS:

The prevalence of microalbuminuria was 2.4%. No differences in the prevalence of microalbuminuria were observed when the different groups of obesity degree were compared (0, 2.2 and 0% in overweight, moderate and severe obese, respectively). A significant relationship emerged between the Log urinary albumin excretion and BMI z-score, waist circumference, Log triglycerides, fasting insulin and HOMA index, adjusted by age and sex. In a multiple regression analysis, the main determinants of Log urinary albumin excretion were sex, waist circumference and Log triglycerides. In 17% of the individuals who fulfil criteria for metabolic syndrome, urinary albumin excretion was significantly higher than those without.

CONCLUSION:

The prevalence of elevated urinary albumin excretion is not prominent in obese children, and when it is increased, it depends mainly on metabolic factors.

PMID:
24096259
DOI:
10.1097/HJH.0b013e328364bcbf
[Indexed for MEDLINE]

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