Format

Send to

Choose Destination
Nanomedicine. 2014 Apr;10(3):619-27. doi: 10.1016/j.nano.2013.09.004. Epub 2013 Oct 2.

Theranostic immunoliposomes for osteoarthritis.

Author information

1
University of Tennessee Health Science Center, Memphis, TN, USA; Campbell Clinnic, Memphis, TN, USA; Veterans Affairs Medical Center, Memphis, TN, USA.
2
Veterans Affairs Medical Center, Memphis, TN, USA.
3
University of Tennessee Health Science Center, Memphis, TN, USA.
4
University of Memphis, Memphis, TN, USA.
5
University of Tennessee Health Science Center, Memphis, TN, USA; Campbell Clinnic, Memphis, TN, USA; Veterans Affairs Medical Center, Memphis, TN, USA. Electronic address: khasty@uthsc.edu.

Abstract

Although there have been substantial advancements in the treatment of inflammatory arthritis, treatments for osteoarthritis (OA) have lagged and currently are primarily palliative until joints become totally dysfunctional and prosthetic replacement is needed. One obstacle for developing a preventive therapy for OA is the lack of good tools for efficiently diagnosing the disease and monitoring its progression during the early stages when the effect of therapeutic drugs or biologics is most likely to be effective. We have developed near infrared immunoliposomes conjugated with type II collagen antibody for diagnosis and treatment of early OA. These immunoliposomes bind to damaged but not normal cartilage. Utilizing these reagents, we can quantitate exposure of type II collagen during cartilage degradation in individual joints in vivo in a guinea pig. Immunoliposomes could be used to determine the effectiveness of therapeutic interventions in small animals as well as vehicles for localized drug delivery to OA chondrocytes.

FROM THE CLINICAL EDITOR:

This team of authors have developed near infrared immunoliposomes conjugated with type II collagen antibody for diagnosis and treatment of early OA, with promising results demonstrated in a guinea pig model.

KEYWORDS:

Extracellular matrix (ECM); Immuno-liposomes (ILs); Near-infrared (NIR) fluorescent; Osteoarthritis (OA); Theranostic (therapeutic and diagnostic); Type II collagen (CII)

PMID:
24096032
PMCID:
PMC4962614
DOI:
10.1016/j.nano.2013.09.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center