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Blood Cells Mol Dis. 2013 Dec;51(4):206-12. doi: 10.1016/j.bcmd.2013.09.005. Epub 2013 Oct 4.

A short history of hemogenic endothelium.

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MRC Molecular Haematology Unit, MRC Weatherall Institute of Medicine, John Radcliffe Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, United Kingdom.


Definitive hematopoietic cells are generated de novo during ontogeny from a specialized subset of endothelium, the so-called hemogenic endothelium. In this review we give a brief overview of the identification of hemogenic endothelium, explore its links with the HSC lineage, and summarize recent insights into the nature of hemogenic endothelium and the microenvironmental and intrinsic regulators contributing to its transition into blood. Ultimately, a better understanding of the processes controlling the transition of endothelium into blood will advance the generation and expansion of hematopoietic stem cells for therapeutic purposes.


AGM; E; EHT; Endothelial to hematopoietic transition; HSC; HSPC; Hematopoiesis; Hematopoietic stem cell; Hemogenic endothelium; Microenvironment; PAS; aorta-gonad mesonephros; embryonic day; endothelial-to-hematopoietic transition; hematopoietic stem and/or progenitor cells; hematopoietic stem cell; para-aortic splanchnopleura

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