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Crit Care Clin. 2013 Oct;29(4):827-39. doi: 10.1016/j.ccc.2013.06.004. Epub 2013 Aug 6.

Overview of severe Clostridium difficile infection.

Author information

1
Section of Acute and Critical Care Surgery, Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110-1093, USA.

Abstract

Clostridium difficile is an anaerobic, spore-forming, gram-positive bacillus that can produce severe colitis resulting in death. There has been an overall increase in the incidence of Clostridium difficile-associated disease and, particularly, an increase in the more virulent forms of the disease. Treatment of severe C difficile infection includes management of severe sepsis and shock, pathogen-directed antibiotic therapy, and, in selected cases, surgical intervention. Ultimately, prevention is the key to limiting the devastating effects of this microorganism.

KEYWORDS:

Clostridium difficile; Clostridium difficile colitis; Nosocomial infection; Pseudomembranous colitis

PMID:
24094379
DOI:
10.1016/j.ccc.2013.06.004
[Indexed for MEDLINE]

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