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Cell Stem Cell. 2013 Oct 3;13(4):379-81. doi: 10.1016/j.stem.2013.09.012.

Removing reprogramming roadblocks: Mbd3 depletion allows deterministic iPSC generation.

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1
Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA.

Abstract

Transcription factor-induced pluripotency is extremely inefficient and assumed to be stochastic. In a recent Nature publication, Rais et al. show that depletion of the methyl-binding protein 3 yields reprogramming efficiencies of up to 100% within days, suggesting that elimination of a single gene suffices to render reprogramming a deterministic process.

PMID:
24094318
DOI:
10.1016/j.stem.2013.09.012
[Indexed for MEDLINE]
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