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BMC Infect Dis. 2013 Oct 5;13:464. doi: 10.1186/1471-2334-13-464.

Clinical and laboratory characteristics of penicilliosis marneffei among patients with and without HIV infection in Northern Thailand: a retrospective study.

Author information

1
Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. rchaiwar@gmail.com.

Abstract

BACKGROUND:

Penicilliosis marneffei is increasingly observed in individuals without HIV infection. This study aimed to compare the clinical and laboratory features among HIV infected and uninfected individuals with penicilliosis marneffei.

METHODS:

A retrospective cohort study was conducted between January 1, 2007 and December 31, 2011 at Chiang Mai University Hospital. We included individuals who were ≥15 years of age and presented with culture-proven P. marneffei infection.

RESULTS:

116 HIV-infected and 34 HIV-uninfected patients were enrolled. Comparing to HIV-infected patients, HIV-uninfected patients were older; less likely to have fever, splenomegaly, and umbilicated skin lesions; more likely to have Sweet's syndrome and bone and joint infections; had higher white blood cell count, platelet count, and CD4 cell count; had lower alanine transaminase (ALT); and less likely to have positive fungal blood cultures. The mortality rates were 20.7% and 29.4% among HIV infected and uninfected patients, respectively.

CONCLUSIONS:

Clinical manifestations of penicilliosis marneffei are different between patients with and without HIV infection. Physician's awareness of this disease in HIV-uninfected patients may prompt the diagnosis and timely treatment, and can lead to a better outcome.

PMID:
24094273
PMCID:
PMC3851520
DOI:
10.1186/1471-2334-13-464
[Indexed for MEDLINE]
Free PMC Article
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