Format

Send to

Choose Destination
Neuron. 2013 Oct 2;80(1):1-3. doi: 10.1016/j.neuron.2013.09.017. Epub 2013 Oct 2.

Excitation BolsTORs motor neurons in ALS mice.

Author information

1
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: mark.mattson@nih.gov.

Abstract

It is unclear why motor neurons selectively degenerate in amyotrophic lateral sclerosis (ALS). Saxena et al. (2013) demonstrate that excitation of motor neurons can prevent their demise in a mouse model of inherited ALS by a mechanism involving the mTOR pathway.

PMID:
24094096
DOI:
10.1016/j.neuron.2013.09.017
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center