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Fetal Pediatr Pathol. 2014 Feb;33(1):16-22. doi: 10.3109/15513815.2013.842270. Epub 2013 Oct 7.

Proportionate reduction in uncertainty of late onset infection in pre-term infants by neutrophil CD64 measurement.

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1
Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Neonatal Service, Royal Victoria Infirmary , Newcastle upon Tyne , United Kingdom.

Abstract

OBJECTIVE:

Establish how neutrophil CD64 performs as a marker of definite infection in pre-term infants in comparison to C reactive protein (CRP) and procalcitonin (PCT).

METHODS:

A total of 38 pre-term infants with suspected late onset infection had CD64 measured by flow cytometry. Proportionate reduction in uncertainty (PRU) curves were generated for CD64 counts at various threshold values.

RESULTS:

PRU curves reduced the residual uncertainty of the presence of infection by up to 64%.

CONCLUSIONS:

The CD64 appears to be a useful point of care test (POCT) for further defining the likelihood of infection and performs better than CRP or PCT at helping to rule in infection.

PMID:
24093544
DOI:
10.3109/15513815.2013.842270
[Indexed for MEDLINE]
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