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Eur J Prev Cardiol. 2015 Feb;22(2):231-9. doi: 10.1177/2047487313506828. Epub 2013 Oct 3.

Skeletal muscle morphology and risk of cardiovascular disease in elderly men.

Author information

1
Uppsala University, Uppsala, Sweden kasper.andersen@medsci.uu.se.
2
Uppsala University, Uppsala, Sweden.
3
Uppsala University, Uppsala, Sweden Högskolan Dalarna, Falun, Sweden.

Abstract

BACKGROUND:

While it is well known that physical inactivity is a major risk factor for cardiovascular disease, there is still a search for the mechanisms by which exercise exerts its positive effect. Skeletal muscle fibre type can be affected to some extent by exercise, and different fibre types possess different anti-inflammatory and glucometabolic properties that may influence cardiovascular disease risk.

DESIGN:

Population-based cohort study.

METHODS:

We investigated relations of skeletal muscle morphology to risk of cardiovascular events in a sample of 466 71-year-old men without cardiovascular disease, of which 295 were physically active (strenuous physical activity at least 3 h/week).

RESULTS:

During a median of 13.1 years of follow up, 173 major cardiovascular events occurred. Among physically active men, 10% higher proportion of type-I (slow-twitch oxidative) fibres was associated with a hazard ratio (HR) of 0.84 (95% confidence interval 0.74-0.95) for cardiovascular events, and 10% higher proportion of type-IIx (fast-twitch glycolytic) fibres was associated with a HR of 1.24 (1.06-1.45), adjusting for age. Similar results were observed in several sets of multivariable-adjusted models. No association of muscle fibre type with risk of cardiovascular events was observed among physically inactive men.

CONCLUSIONS:

Higher skeletal muscle proportion of type-I fibres was associated with lower risk of cardiovascular events and a higher proportion of type-IIx fibres was associated with higher risk of cardiovascular events. These relations were only observed in physically active men. Skeletal muscle fibre composition may be a mediator of the protective effects of exercise against cardiovascular disease.

KEYWORDS:

Cardiovascular diseases; cytokines; insulin resistance; physical activity; skeletal muscle fibres

PMID:
24092874
DOI:
10.1177/2047487313506828
[Indexed for MEDLINE]

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