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Autophagy. 2013 Nov 1;9(11):1720-36. doi: 10.4161/auto.26550. Epub 2013 Sep 26.

Regulation and function of mitophagy in development and cancer.

Author information

1
Laboratory of Cancer Biology; Institute of Clinical Science; Sir Run Run Shaw Hospital; School of Medicine; Zhejiang University; Hangzhou, Zhejiang China; Department of Medical Oncology; Sir Run Run Shaw Hospital; School of Medicine; Zhejiang University; Hangzhou; Zhejiang China.

Abstract

Beyond its role in recycling intracellular components nonselectively to sustain survival in response to metabolic stresses, autophagy can also selectively degrade specific cargoes such as damaged or dysfunctional organelles to maintain cellular homeostasis. Mitochondria, known as the power plant of cells, are the critical and dynamic organelles playing a fundamental role in cellular metabolism. Mitophagy, the selective autophagic elimination of mitochondria, has been identified both in yeast and in mammalian cells. Moreover, defects in mitophagy may contribute to a variety of human disorders such as neurodegeneration and myopathies. However, the role of mitophagy in development and cancer remains largely unclear. In this review, we summarize our current knowledge of the regulation and function of mitophagy in development and cancer.

KEYWORDS:

Warburg effect; autophagy; cancer; development; energy metabolism; mitochondria; mitophagy; tumor microenvironment; tumorigenesis

PMID:
24091872
DOI:
10.4161/auto.26550
[Indexed for MEDLINE]

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