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J Infect. 2014 Feb;68(2):165-9. doi: 10.1016/j.jinf.2013.09.028. Epub 2013 Oct 1.

Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in patients with tick-borne encephalitis.

Author information

1
Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská 31, CZ-37005 České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 31, CZ-37005 České Budějovice, Czech Republic.
2
Department of Virology, Hospital České Budějovice, Boženy Němcové 585/54, CZ-37001 České Budějovice, Czech Republic.
3
Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská 31, CZ-37005 České Budějovice, Czech Republic; Department of Virology, Veterinary Research Institute, Hudcova 70, CZ-62100 Brno, Czech Republic. Electronic address: ruzekd@paru.cas.cz.

Abstract

OBJECTIVES:

Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) play important roles in the function of the blood-brain barrier (BBB). To investigate the function of the BBB during tick-borne encephalitis (TBE), the levels of MMP-9 and its common tissue inhibitor, TIMP-1, were measured in serum from patients with acute phase of TBE.

METHODS:

Serum MMP-9 and TIMP-1 levels were measured in 147 patients with TBE and 153 controls by ELISA.

RESULTS:

Serum MMP-9 levels and MMP-9/TIMP-1 ratios of TBE patients were significantly higher than controls (p < 0.0001 and p < 0.005, respectively). There were no significant differences in serum TIMP-1 levels between TBE patients and controls. Serum MMP-9 and TIMP-1 levels and MMP-9/TIMP-1 ratios were not associated with age of the patients. However, TBE-positive males with TBE had higher levels of MMP-9 than TBE-positive females (p < 0.05).

CONCLUSIONS:

Our results suggest that the increased serum level of MMP-9 and MMP-9/TIMP-1 ratio is associated with the pathogenesis of TBE. Serum MMP-9 can serve as an indicator of breakdown of the BBB and inflammatory brain damage during TBE.

KEYWORDS:

Blood–brain barrier; Matrix metalloproteinase-9; Tick-borne encephalitis; Tissue inhibitor of metalloproteinase-1

PMID:
24091083
DOI:
10.1016/j.jinf.2013.09.028
[Indexed for MEDLINE]

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