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Trends Genet. 2014 Jan;30(1):10-7. doi: 10.1016/j.tig.2013.09.001. Epub 2013 Sep 30.

Roles of cilia, fluid flow, and Ca2+ signaling in breaking of left-right symmetry.

Author information

1
Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address: syoshiba@nig.ac.jp.
2
Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address: hamada@fbs.osaka-u.ac.jp.

Abstract

The emergence of left-right (L-R) asymmetry during embryogenesis is a classic problem in developmental biology. It is only since the 1990s, however, that substantial insight into this problem has been achieved by molecular and genetic approaches. Various genes required for L-R asymmetric morphogenesis in vertebrates have now been identified, and many of these genes are required for the formation and motility of cilia. Breaking of L-R symmetry in the mouse embryo occurs in the ventral node, where two types of cilia are present. Whereas centrally located motile cilia generate a leftward fluid flow, peripherally located immotile cilia sense a flow-dependent signal, which is either chemical or mechanical in nature. Although Ca2+ signaling is implicated in flow sensing, the precise mechanism remains unknown. Here we summarize current knowledge of L-R symmetry breaking in vertebrates (focusing on the mouse), with a special emphasis on the roles of cilia, fluid flow, and Ca2+ signaling.

KEYWORDS:

cilia; fluid flow; left–right asymmetry

PMID:
24091059
DOI:
10.1016/j.tig.2013.09.001
[Indexed for MEDLINE]

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