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Small GTPases. 2013 Jul-Sep;4(3):148-58. doi: 10.4161/sgtp.25604. Epub 2013 Jul 30.

Functional role(s) of phagosomal Rab GTPases.

Author information

1
Division of Mycobacterial Research; Medical Research Council; National Institute for Medical Research; London, UK.

Abstract

Rab GTPases are at the central node of the machinery that regulates trafficking of organelles, including phagosomes. Thanks to the unique combination of high quality phagosome purification with highly sensitive proteomic studies, the network of Rab proteins that are dynamically associated with phagosomes during the process of maturation of this organelle is relatively well known. Whereas the phagosomal functions of many of the Rab proteins associated with phagosomes are characterized, the role(s) of most of these trafficking regulators remains to be identified. In some cases, even when the function in the context of phagosome biology is described, phagosomal Rab proteins seem to have similar roles. This review summarizes the current knowledge about the identity and function of phagosomal Rab GTPases, with a particular emphasis on new evidence that clarify these seemingly overlapping Rab functions during phagosome maturation.

KEYWORDS:

Rab; autophagosome; bacteria; lysosome; phagosome

PMID:
24088602
PMCID:
PMC3976971
DOI:
10.4161/sgtp.25604
[Indexed for MEDLINE]
Free PMC Article

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