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J Thorac Cardiovasc Surg. 2014 Jan;147(1):412-7. doi: 10.1016/j.jtcvs.2013.08.034. Epub 2013 Sep 29.

Management of tricuspid regurgitation in congenital heart disease: is survival better with valve repair?

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Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minn.
Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minn. Electronic address:
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn.
Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minn.
Division of Cardiac Anesthesia, Mayo Clinic, Rochester, Minn.



Tricuspid valve (TV) regurgitation in congenital heart disease includes a heterogeneous group of lesions, and few series have documented the outcomes.


We reviewed the records of 553 patients with congenital heart disease who had undergone TV surgery for tricuspid regurgitation from January 1993 to December 2010. Patients with Ebstein malformation were excluded. Their mean age was 32 ± 21 years, and 300 were female (54%). The most common diagnoses were conotruncal anomaly in 216 patients (39%), previous ventricular septal defect closure in 83 (15%), atrioventricular septal defect in 77 (14%), and pulmonary atresia with an intact ventricular septum in 11 (2%). Preoperative right-sided heart failure was present in 124 patients (22%), and 55 patients (10%) had pulmonary hypertension.


TV repair was performed in 442 (80%) and TV replacement in 111 (20%) patients. Repeat sternotomy was performed in 415 patients (75%). Previous TV repair was present in 44 patients (8%); of these, 17 (38.6%) underwent repeat TV repair. The overall early mortality was 3.1% (17 patients) and was 2.5% for TV repair and 5.4% for TV replacement (P = .001). The mean follow-up period was 4.5 ± 4.1 years (maximum, 18). The overall survival at 1, 5, and 10 years was 97%, 93%, and 85%, respectively. Survival was better for patients with repair than with replacement. TV repair was an independent predictor of better survival (P = .001).


Important tricuspid regurgitation can occur with a variety of congenital diagnoses. Early mortality is low and late survival is superior with tricuspid repair than with valve replacement. Surgical treatment of tricuspid regurgitation in congenital heart disease should be performed before the onset of heart failure.


20; 35; AVSD; EM; Ebstein malformation; ICD; TR; TV; VSD; atrioventricular septal defect; implantable cardiac defibrillator; tricuspid regurgitation; tricuspid valve; ventricular septal defect

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