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Ther Adv Urol. 2013 Oct;5(5):245-53. doi: 10.1177/1756287213498923.

Holmium laser enucleation of the prostate: a paradigm shift in benign prostatic hyperplasia surgery.

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Department of Urology, Cambridge University, Addenbrookes Hospital, Hills Rd, Cambridge, CB22 5AN, UK.


Holmium laser enucleation (HoLEP) was developed in the 1990s as a more efficient and cost effective method of benign prostatic hyperplasia surgery than laser vaporization and resection techniques. As a true anatomical enucleation it mimics open prostatectomy and is as durable. There is a significant body of level 1 evidence in support of HoLEP, including 2 meta-analyses and 14 randomized trials which compare HoLEP with a number of other procedures. This review describes the development of and summarizes the evidence for HoLEP.


HoLEP; benign prostatic hyperplasia; holmium laser enucleation of the prostate; lower urinary tract symptoms; prostate

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