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Toxicol Ind Health. 2016 Feb;32(2):193-9. doi: 10.1177/0748233713498924. Epub 2013 Sep 30.

Serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal cell carcinoma.

Author information

1
Department of Urology, Yuzuncu Yıl University, Van, Turkey necippirincci@hotmail.com.
2
Van Training and Research Hospital, Urology Clinic, Van, Turkey.
3
Department of Urology, Yuzuncu Yıl University, Van, Turkey.
4
Department of Urology, Celal Bayar University, Manısa, Turkey.
5
Department of Urology, Bozok University, Yozgat, Turkey.
6
Department of Chemistry, Yuzuncu Yıl University, Van, Turkey.

Abstract

OBJECTIVES:

Prolidase is a member of the matrix metalloproteinase family. It plays a vital role in collagen turnover, matrix remodeling, and cell growth. Reactive oxygen species (ROS) have been implicated in the pathogenesis of various diseases, including cancers. Oxidative stress can cause tumor angiogenesis and may be carcinogenic. However, the relationship between antioxidant capacity and various cancers has been researched in several clinical trials. In our study, we aimed to identify serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal tumors and to evaluate their relationships with each other.

MATERIALS AND METHODS:

A total of 37 male patients with renal cell cancer and with a mean age of 56.28 ± 3.1 were included in the study. The control group comprising 36 male patients (mean age 56.31 ± 2.9) was randomly selected among the volunteers. Serum samples for measurement of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione-S-transferase (GST), malondialdehyde (MDA), glutathione (GSH), and prolidase levels were kept at -20°C until they were used.

RESULTS:

Serum prolidase activity and MDA levels were significantly higher in renal cancer patients than in controls (all, p < 0.05), while SOD, GSHPx, and GST levels were significantly lower (p < 0.05).

CONCLUSION:

Our results indicate that increased prolidase seems to be related to increased oxidative stress along with decreased antioxidant levels in renal cancer.

KEYWORDS:

Glutathione peroxidase; malondialdehyde; prolidase activity; renal cell carcinoma; superoxide dismutase

PMID:
24081636
DOI:
10.1177/0748233713498924
[Indexed for MEDLINE]
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