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Nanoscale. 2013 Nov 21;5(22):11179-86. doi: 10.1039/c3nr03669c. Epub 2013 Sep 30.

In vivo pulsed magneto-motive ultrasound imaging using high-performance magnetoactive contrast nanoagents.

Author information

1
Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA. emelian@mail.utexas.edu.

Abstract

Previously, pulsed magneto-motive ultrasound (pMMUS) imaging has been introduced as a contrast-agent-assisted ultrasound-based imaging modality capable of visualizing biological events at the cellular and molecular level. In pMMUS imaging, a high intensity pulsed magnetic field is used to excite cells or tissue labeled with magnetic nanoparticles. Then, ultrasound (US) imaging is used to monitor the mechanical response of the tissue to an externally applied magnetic field (i.e., tissue displacement). Signal to noise ratio (SNR) in pMMUS imaging can be improved by using superparamagnetic nanoparticles with larger saturation magnetization. Metal-doped magnetic nanoparticles with enhanced tunable nanomagnetism are suitable candidates to improve the SNR and, therefore, sensitivity of pMMUS imaging, which is essential for in vivo pMMUS imaging. In this study, we demonstrate the capability of pMMUS imaging to identify the presence and distribution of zinc-doped iron oxide nanoparticles in live nude mice bearing A431 (human epithelial carcinoma) xenograft tumors.

PMID:
24080913
PMCID:
PMC3916332
DOI:
10.1039/c3nr03669c
[Indexed for MEDLINE]
Free PMC Article
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