Format

Send to

Choose Destination
Neurobiol Aging. 2014 Feb;35(2):442.e9-442.e16. doi: 10.1016/j.neurobiolaging.2013.07.011. Epub 2013 Sep 27.

Assessment of Parkinson's disease risk loci in Greece.

Author information

1
Reta Lila Weston Laboratories and Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.

Abstract

Genome-wide association studies (GWAS) have been shown to be a powerful approach to identify risk loci for neurodegenerative diseases. Recent GWAS in Parkinson's disease (PD) have been successful in identifying numerous risk variants pointing to novel pathways potentially implicated in the pathogenesis of PD. Contributing to these GWAS efforts, we performed genotyping of previously identified risk alleles in PD patients and control subjects from Greece. We showed that previously published risk profiles for Northern European and American populations are also applicable to the Greek population. In addition, although our study was largely underpowered to detect individual associations, we replicated 5 of 32 previously published risk variants with nominal p values <0.05. Genome-wide complex trait analysis revealed that known risk loci explain disease risk in 1.27% of Greek PD patients. Collectively, these results indicate that there is likely a substantial genetic component to PD in Greece, similarly to other worldwide populations, that remains to be discovered.

KEYWORDS:

GCTA; GWAS; Genetics; Greece; Parkinson's disease; Risk profiles

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center