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Clin Dermatol. 2013 Sep-Oct;31(5):627-49. doi: 10.1016/j.clindermatol.2013.06.018.

Nail abnormalities associated with systemic pathologies.

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Chairman, Department of Dermatology, Herbert Wertheim College of Medicine, Florida International University; Director, Greater Miami Skin and Laser Center, Mount Sinai Medical Center, 4308 Alton Road, Suite 750, Miami Beach, FL 33140. Electronic address:


Nail abnormalities can arise in conjunction with or as a result of systematic pathologies. These pathologies include single-organ diseases, multisystemic diseases, and drug-induced insults. Clinical signs associated with these conditions include dyschromias, vascular alterations, periungual tissue changes, textural dystrophies, contour alterations, and growth-rate alterations. The associated systemic pathologies may affect any part of the nail apparatus, including the nail matrix, the nail plate, the nail bed, the underlying vasculature, and the periungual tissues. The anatomical location and extent of damage determine the clinically manifested anomaly.

[Indexed for MEDLINE]

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