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Fetal Pediatr Pathol. 2014 Feb;33(1):1-8. doi: 10.3109/15513815.2013.839011. Epub 2013 Sep 30.

Clinicopathological and extensive immunohistochemical study of a type II pleuropulmonary blastoma.

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Department of Pathology, Xijing Hospital, Fourth Military Medical University , Xi'an , China.


Pleuropulmonary blastoma (PPB) is a rare malignant dysontogenetic neoplasm primarily affecting younger children, even in newborns with an unfavorable outcome. PPB is histologically composed of a primitive, variably mixed blastematous and sarcomatous components, and exclusively subclassified as type I (purely cystic), type II (both cystic and solid elements) and type III (completely solid) by increasing histological evidence of malignancy. At present, well-documented cases or cases of truly precise presentation of either pathological or immunohistochemical findings in PPB are rare. The authors report one case of PPB in a 44-month-old child presenting as a solid and cystic mass with special emphasis on its radiological, histopathological and immunohistochemical aspects. The histological diagnosis was PPB, which would belong to the type II category.

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