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Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Oct;30(5):622-5. doi: 10.3760/cma.j.issn.1003-9406.2013.05.026.

[Analysis of allele dropout at TH01 locus in paternity testing].

[Article in Chinese]

Author information

1
Forensic Science Institute of Fujian Provincial Hospital, Fujian Provincial Key Laboratory of Cardiovascular Disease, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian 350001, P. R. China. Email: sxli3318@163.com.

Abstract

OBJECTIVE:

To analyze allele dropout at TH01 locus in paternity testing in order to determine the accurate genotype.

METHODS:

To use a two STR loci genotyping system to verify an abnormal genotype for the TH01 locus with PCR using specific primers, cloning and DNA sequencing.

RESULTS:

A rare allele at TH01 locus named 5.2, which was undetectable with PowerPlex 21 system, was detected with an Identifiler system.

CONCLUSION:

Genetic variations may result in rare alleles and loci loss. To avoid misjudgment, laboratories should have a variety of methods for detecting loci loss.

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