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Birth Defects Res A Clin Mol Teratol. 2013 Sep;97(9):602-9. doi: 10.1002/bdra.23177.

Neural tube defects, folate, and immune modulation.

Author information

1
School of Biomedical Sciences, The University of Queensland, St Lucia, Brisbane, Australia; Royal Brisbane and Women's Hospital, Herston, Brisbane, Australia.

Abstract

Periconceptional supplementation with folic acid has led to a significant worldwide reduction in the incidence of neural tube defects (NTDs). However, despite increasing awareness of the benefits of folic acid supplementation and the implementation of food fortification programs in many countries, NTDs continue to be a leading cause of perinatal morbidity and mortality worldwide. Furthermore, there exists a significant subgroup of women who appear to be resistant to the protective effects of folic acid supplementation. The following review addresses emerging clinical and experimental evidence for a role of the immune system in the etiopathogenesis of NTDs, with the aim of developing novel preventative strategies to further reduce the incidence of NTD-affected pregnancies. In particular, recent studies demonstrating novel roles and interactions between innate immune factors such as the complement cascade, neurulation, and folate metabolism are explored.

KEYWORDS:

C5a; complement; folate; neural tube defects; neurulation

PMID:
24078477
PMCID:
PMC4053177
DOI:
10.1002/bdra.23177
[Indexed for MEDLINE]
Free PMC Article
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