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Nat Neurosci. 2013 Nov;16(11):1551-2. doi: 10.1038/nn.3535. Epub 2013 Sep 29.

Category-specific integration of homeostatic signals in caudal but not rostral human insula.

Author information

1
1] Laureate Institute for Brain Research, Tulsa, Oklahoma, USA. [2] Faculty of Community Medicine, The University of Tulsa, Tulsa, Oklahoma, USA. [3] Laboratory of Brain and Cognition, National Institute of Mental Health (NIHM), National Institutes of Health (NIH), Bethesda, Maryland, USA.

Abstract

Prevailing theories hold that the insula is functionally organized along its caudal-to-rostral axis, with posterior regions coding lower-level sensory information and anterior regions coding higher-level stimulus significance relative to the body's homeostatic needs. Contrary to predictions of this model, the response of the taste-sensitive region of the caudal, but not rostral, insula to food images was directly related to the body's homeostatic state as indexed by levels of peripheral glucose.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00846040.

PMID:
24077565
PMCID:
PMC3835665
DOI:
10.1038/nn.3535
[Indexed for MEDLINE]
Free PMC Article

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