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Iran J Immunol. 2013 Sep;10(3):177-85. doi: IJIv10i3A6.

Interleukin-17 gene expression and serum levels in children with severe asthma.

Author information

1
Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, e-mail: alyasins@sums.ac.ir.

Abstract

BACKGROUND:

IL-17 is a major cytokine player in T cell mediated leukocyte associated inflammation. IL-17 is also recognized to participate in the pathophysiology of asthma.

OBJECTIVE:

To determine the role of IL-17 in predicting severe asthma.

METHODS:

We obtained serum samples from asthmatic children under the age of 5-year in three different groups of mild (n=33), moderate (n=28) and severe (n=32) persistent asthma. IL-17 serum concentrations and mRNA expression were determined by ELISA and real time PCR assays, respectively.

RESULTS:

Serum IL-17 concentrations were significantly higher in patients with severe asthma than the other two groups of children with mild and moderate disease (p=0.00). Mean serum IL-17 values were 142.04 pg/ml in mild group, 180.4 pg/ml in moderate group and 251.25 pg/ml in severe group. IL-17 mRNA levels were also significantly elevated in severe asthmatic patients compared to mild and moderate asthmatic children (p=0.00).

CONCLUSION:

Our data reveal an increase in the serum IL-17 concentration and IL-17 mRNA expression in children with severe asthma compared to those with mild and moderate forms of the disease.

PMID:
24076595
DOI:
IJIv10i3A6
[Indexed for MEDLINE]
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