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J Mol Biol. 2013 Dec 13;425(24):4937-55. doi: 10.1016/j.jmb.2013.09.024. Epub 2013 Sep 25.

IFITMs restrict the replication of multiple pathogenic viruses.

Author information

  • 1Microbiology and Physiological Systems (MaPS) Department, University of Massachusetts Medical School, Albert Sherman Center 8 1001, 368 Plantation Street, Worcester, MA 01655, USA.

Abstract

The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and Ebola virus. This review covers recent developments in our understanding of the IFITM's molecular determinants, potential mechanisms of action, and impact on pathogenesis.

KEYWORDS:

AS; CCHFV; CD225 family; CIL; CMEM; Crimean Congo hemorrhagic fever virus; DENV; EBOV; Ebola virus; GP; HCV; HIV-1; IAV; IFITM; IFN; JSRV; Jaagsiekte sheep retrovirus; MARV; MLV; MS; Marburg virus; Moloney leukemia virus; N-terminal domain; NTD; OSBP; RVFV; Rift Valley fever virus; SARS CoV; SeV; Sendai virus; VAPA; alanine scanning; clathrin-mediated endocytosis motif; conserved intracellular loop; dengue virus; glycoprotein; hepatitis C virus; host virus interactions; human immunodeficiency virus type 1; influenza A virus; interferon; interferon effector genes; interferon-inducible transmembrane protein; mass spectrometry; oxysterol binding protein; restriction factor; severe acute respiratory syndrome coronavirus; vesicle-associated membrane protein-A

PMID:
24076421
PMCID:
PMC4121887
DOI:
10.1016/j.jmb.2013.09.024
[PubMed - indexed for MEDLINE]
Free PMC Article
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