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Immunol Lett. 2013 Sep-Oct;155(1-2):18-20. doi: 10.1016/j.imlet.2013.09.018. Epub 2013 Sep 25.

Hematopoietic defects and iPSC disease modeling: lessons learned.

Author information

1
Department of Pathology, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA.

Abstract

Hematopoiesis is a paradigm for stem cell biology in that it centers on differentiation of a self-renewing pluripotent precursor into multiple committed cell types with specific functions. The use of induced pluripotent stem cells (iPSCs) as a disease modeling tool has revealed numerous insights into the underlying pathophysiology of hematological diseases - those disorders arising from defective hematopoiesis. Likewise, studying hematopoiesis and the defects that can arise offer clues to understanding general stem cell survival and differentiation.

KEYWORDS:

Bone marrow failure; Disease modeling; Induced pluripotent stem cells; Reprogramming

PMID:
24076116
PMCID:
PMC3888024
DOI:
10.1016/j.imlet.2013.09.018
[Indexed for MEDLINE]
Free PMC Article

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