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Cancer Epidemiol. 2013 Dec;37(6):905-7. doi: 10.1016/j.canep.2013.09.007. Epub 2013 Sep 27.

Vitamin D receptor polymorphism and colorectal cancer-specific and all-cause mortality.

Author information

1
German Cancer Research Center (DKFZ) - Division of Clinical Epidemiology and Aging Research, Im Neuenheimer Feld, 581-69120 Heidelberg, Germany. Electronic address: l.perna@dkfz-heidelberg.de.

Abstract

BACKGROUND:

The vitamin D receptor (VDR) gene is present in colorectal cancer (CRC) cells and its genetic variants have been associated with an increased risk of CRC. The association with colorectal cancer prognosis remains widely unexplored.

METHODS:

1397 colorectal cancer patients participating in two cancer cohorts (ESTHER II and VERDI) and in a population-based case-control study (DACHS) were followed for 5 years. Unadjusted and adjusted hazard ratios for all-cause mortality (469 events) and CRC-specific mortality (336 events) were estimated for VDR variants rs731236 (TaqI), rs2228570 (FokI), rs11568820 (Cdx2), and rs1989969 (VDR-5132).

RESULTS:

No association was found between VDR polymorphism and CRC specific and all-cause mortality. Adjusted hazard ratios ranged from 0.79 (95% CI 0.57-1.12) to 1.14 (95% CI 0.89-1.46) for CRC-specific mortality and from 0.89 (95% CI 0.67-1.18) to 1.22 (95% CI 0.99-1.50) for all-cause mortality. All 95% confidence intervals included the null value.

CONCLUSIONS:

Our findings do not support the hypothesis that the common VDR gene variants investigated in this study are of clinical relevance with respect to CRC prognosis.

KEYWORDS:

Cancer prognosis; Colorectal cancer; VDR polymorphism; Vitamin D

PMID:
24075799
DOI:
10.1016/j.canep.2013.09.007
[Indexed for MEDLINE]

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