Format

Send to

Choose Destination
See comment in PubMed Commons below
Phytochemistry. 2013 Dec;96:457-64. doi: 10.1016/j.phytochem.2013.09.007. Epub 2013 Sep 26.

Solanidane and iminosolanidane alkaloids from Solanum campaniforme.

Author information

1
Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, 12.200, Fortaleza-CE 60.021-970, Brazil.

Abstract

From the leaves of Solanum campaniforme (Solanaceae), eight solanidane alkaloids were isolated, four of which contain a p-hydroxyphenylethylamine unit. Their structures were established as: 22β,23β-epoxy-solanida-1,4-dien-3-one; 22α,23α-epoxy-10-epi-solanida-1,4,9-trien-3-one; 22α,23α-epoxy-solanida-4-en-3-one; 22β,23β-epoxy-solanida-4-en-3-one; (E)-N-[8'(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4,9-trien-3-imine; (E)-N-[8'(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4-dien-3-imine; (Z)-N-[8'(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4,9-trien-3-imine and (Z)-N-[8'(4-hydroxyphenyl)ethyl]-22α,23α-epoxy-solanida-1,4-dien-3-imine. All structures were determined using spectroscopic techniques, such as 1D and 2D NMR, and HRESIMS. The cytotoxicity and the antiophidic activities of the alkaloids were evaluated. The alkaloids did not show any cytotoxicity, but inhibited the main toxic actions of Bothrops pauloensis venom.

KEYWORDS:

Bothrops pauloensis; Iminosolanidane alkaloids; Solanaceae; Solanidane alkaloids; Solanum campaniforme

PMID:
24075572
DOI:
10.1016/j.phytochem.2013.09.007
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center