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Cell. 2013 Sep 26;155(1):15-6. doi: 10.1016/j.cell.2013.09.012.

For genomes to stay in shape, insulators must be up to PAR.

Author information

1
Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.

Abstract

Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.

PMID:
24074855
DOI:
10.1016/j.cell.2013.09.012
[Indexed for MEDLINE]
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