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Biomaterials. 2013 Dec;34(38):9763-9. doi: 10.1016/j.biomaterials.2013.09.021. Epub 2013 Sep 25.

A photo-triggered layered surface coating producing reactive oxygen species.

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Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.


We report a photoactive surface coating which produces cytotoxic reactive oxygen species (ROS) upon irradiation with near infrared (NIR) light. The coating is assembled layer-by-layer, and consists of cross-linked hyaluronic acid (HA) and poly-l-lysine (PLL) modified with the photoactive molecule pheophorbide a. Pheophorbide a loading can be fine-tuned by varying the number of bilayers, yielding stable materials with the capacity to generate repeated and/or prolonged light-triggered ROS release. Light irradiation of the photoactive surface coatings provides a versatile platform for the spatiotemporal control of events at the material-tissue interface, such as bacterial colonization, platelet adhesion, and mammalian cell attachment.


Coating; Layer by layer; Photo-triggered; Reactive oxygen species

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