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Expert Rev Cardiovasc Ther. 2013 Sep;11(9):1247-57. doi: 10.1586/14779072.2013.832482.

Enterococcus faecalis infective endocarditis: focus on clinical aspects.

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Gentofte University Hospital, Niels Andersens vej 65, 2900 Hellerup, Denmark.


Enterococcus faecalis infective endocarditis (IE) is a disease of increasing importance, with more patients infected, increasing frequency of health-care associated infections and increasing incidence of antimicrobial resistances. The typical clinical presentation is a subacute course with fever, malaise and generalized aches, difficult to distinguish from other more common diseases. Of paramount importance is transthoracic- and transesophageal-echocardiography to establish the diagnosis. At the moment, the predominant strategies recommend ampicillin in combination with either gentamicin or ceftriaxone. E. faecalis infective endocarditis continues to be a very serious disease with considerable percentages of high-level gentamicin resistant strains and in-hospital mortality around 20%. Strategies to prevent E. faecalis IE, improve diagnostics, optimize treatment and reduce morbidity will be necessary to improve the overall prognosis.

[Indexed for MEDLINE]

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