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Oncoimmunology. 2013 Jul 1;2(7):e24661. Epub 2013 Apr 30.

Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination.

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1
Department of Tumor Immunology; Nijmegen Centre for Molecular Life Sciences; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands ; Department of Medical Oncology; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands ; Department of Nuclear Medicine; Radboud University Nijmegen Medical Centre; Nijmegen, The Netherlands.

Abstract

Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the conditioning of the injection site, improved LN targeting.

KEYWORDS:

19F MRI; dendritic cell; imaging; immunotherapy; migration

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