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Oncoimmunology. 2013 Jul 1;2(7):e24659. Epub 2013 Apr 30.

Bone marrow provides an environment that prevents suppression of therapeutic graft-vs.-tumor immunity by regulatory T cells.

Author information

  • 1Center for Immunology of Infectious Diseases and Vaccines; Netherlands Institute for Health and the Environment (RIVM); Bilthoven, The Netherlands.

Abstract

Regulatory T cells (Tregs) can prevent graft-vs.-host disease as induced by the infusion of donor lymphocytes to cancer patients, but often they also suppress therapeutic antitumor immunity. We discuss an exception to this phenomenon, exemplifying how the milieu provided by the bone marrow may neutralize Tregs to allow local immune responses against cancer.

KEYWORDS:

bone marrow; graft-vs.-host disease; graft-vs.-tumor; lymphocyte infusion; regulatory T cell

PMID:
24073360
PMCID:
PMC3782161
DOI:
10.4161/onci.24659
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