Send to

Choose Destination
See comment in PubMed Commons below
Science. 2013 Nov 1;342(6158):611-4. doi: 10.1126/science.1242603. Epub 2013 Sep 26.

Real-space identification of intermolecular bonding with atomic force microscopy.

Author information

Key Laboratory of Standardization and Measurement for Nanotechnology, Chinese Academy of Sciences, National Center for Nanoscience and Technology, Beijing 100190, China.


We report a real-space visualization of the formation of hydrogen bonding in 8-hydroxyquinoline (8-hq) molecular assemblies on a Cu(111) substrate, using noncontact atomic force microscopy (NC-AFM). The atomically resolved molecular structures enable a precise determination of the characteristics of hydrogen bonding networks, including the bonding sites, orientations, and lengths. The observation of bond contrast was interpreted by ab initio density functional calculations, which indicated the electron density contribution from the hybridized electronic state of the hydrogen bond. Intermolecular coordination between the dehydrogenated 8-hq and Cu adatoms was also revealed by the submolecular resolution AFM characterization. The direct identification of local bonding configurations by NC-AFM would facilitate detailed investigations of intermolecular interactions in complex molecules with multiple active sites.

Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center