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Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Sep;38(9):966-70. doi: 10.3969/j.issn.1672-7347.2013.09.017.

[Diagnosis and treatment of ketamine-associated cystitis: a report of 3 cases and literature review].

[Article in Chinese]

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1
Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.

Abstract

OBJECTIVE:

To determine the diagnosis, treatment, and pathogenesis of ketamine-associated cystitis.

METHODS:

Clinical data from 3 patients with ketamine-associated cystitis were analyzed retrospectively and discussed in light of relevant literature.

RESULTS:

In the 3 cases, 2 presented severe lower urinary tract symptoms, including frequency, urgency, dysuria, urge incontinence, and painful haematuria. Urinalysis and urine culture were negative. Imaging examination demonstrated thickening of the bladder wall and a small capacity. Inflammatory changes in the bladder mucosa were observed by cystoscopy and biopsies. After cessation of ketamine use, with the addition of steroids or hydrodistension, the symptoms in the 3 patients improved. The symptoms recurred in 2 patients, as 1 was exposed to ketamine again and 1 had severe bladder contraction after for 3 - 4 month follow-up.

CONCLUSION:

Ketamine-associated cystitis is a new urinary system inflammatory damage. Its etiology and treatment methods are not clear. Early abstinence from ketamine use and early treatment are crucial for patients with ketamine-associated cystitis to avoid irreversible damage.

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