Format

Send to

Choose Destination
See comment in PubMed Commons below
Behav Brain Res. 2013 Nov 15;257:8-12. doi: 10.1016/j.bbr.2013.09.029. Epub 2013 Sep 23.

7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice.

Author information

  • 1Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Maastricht University, The Netherlands.

Abstract

Brain-derived neurotrophic factor (BDNF) is a crucial regulator of neuronal survival and neuroplasticity in the central nervous system (CNS). As a result, there has been a growing interest in the role of BDNF in neuropsychiatric disorders associated with neurodegeneration, including depression and dementia. However, until now, BDNF-targeting therapies have yielded disappointing results. BDNF is thought to exert its beneficial effects on synaptic and neuronal plasticity mainly through binding to the tyrosine kinase B (TrkB) receptor. Recently, 7,8-dihydroxyflavone (7,8-DHF) was identified as the first selective TrkB agonist. In the present study the effect of 7,8-DHF on memory consolidation processes was evaluated. In healthy rats, 7,8-DHF improved object memory formation in the object recognition task when administered both immediately and 3h after learning. In a transgenic mouse model of Alzheimer's disease, i.e. APPswe/PS1dE9 mice, spatial memory as measured in the object location task was improved after administration of 7,8-DHF. A similar memory improvement was found when their wild-type littermates were treated with 7,8-DHF. The acute beneficial effects in healthy mice suggest that effects might be symptomatic rather than curing. Nevertheless, this study suggests that 7,8-DHF might be a promising therapeutic target for dementia.

KEYWORDS:

7,8-DHF; 7,8-Dihydroxyflavone; 7,8-dihydroxyflavone; AD; Alzheimer's disease; Aβ; BDNF; Brain-derived neurotrophic factor; CNS; CREB; Ca(2+)/calmodulin-dependent protein kinase II; CaMKII; Cognition enhancers; LTP; Memory consolidation; N-methyl-d-aspartic acid; NMDA; OLT; ORT; PTSD; T1; T2; TrkB; TrkB receptor; WT; amyloid beta; brain-derived neurotrophic factor; cAMP-responsive element binding; central nervous system; first trial; i.p.; intraperitoneal; long-term potentiation; mBDNF; mature BDNF; object location task; object recognition task; p.o.; per os; post-traumatic stress disorder; precursor of BDNF; proBDNF; second trial; tyrosine kinase B; wild-type

PMID:
24070857
DOI:
10.1016/j.bbr.2013.09.029
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center