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Ultrasonics. 2014 Jul;54(5):1170-7. doi: 10.1016/j.ultras.2013.08.017. Epub 2013 Sep 10.

Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: clinical findings.

Author information

1
Artann Laboratories, Trenton, NJ 08618, USA. Electronic address: vegorov@artannlabs.com.
2
Artann Laboratories, Trenton, NJ 08618, USA.
3
Health Smart Medical Center, Philadelphia, PA 19115, USA.
4
Mayo Clinic, Rochester, MN 55905, USA.
5
Catholic Health, Sisters of Charity Hospital, Buffalo, NY 14214, USA.

Abstract

The objective of this study was to evaluate if the Bone UltraSonic Scanner (BUSS) can detect osteoporosis in postmenopausal women. BUSS is an axial transmission multi-frequency ultrasonometer for acquisition of wave propagation profiles along the proximal anterior tibia. We derived 10 diagnostically significant BUSS parameters that were then compared with the DXA spine T-score, which was used in this study as the "gold standard" for the assessment of osteoporosis (T-score<-2.5). BUSS wave parameters were studied in 331 postmenopausal women examined by 9 trained operators at 3 clinical sites with use of 3 devices. The efficiency of each BUSS parameter in osteoporosis detection was assessed using a receiver operating characteristic curve analysis. Area under the curve (AUC) for each of 10 parameters ranged from 58.1% to 70.2%. Using these parameters a linear classifier was derived which provided at its output 83.0% AUC, 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis. The results of this study confirm BUSS's capability to detect osteoporosis in postmenopausal women.

KEYWORDS:

Axial scanning; Bone quantitative ultrasound; Multi-frequency; Osteoporosis; Wave propagation parameters

PMID:
24070826
PMCID:
PMC3951708
DOI:
10.1016/j.ultras.2013.08.017
[Indexed for MEDLINE]
Free PMC Article
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