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Genes Cancer. 2013 May;4(5-6):235-41. doi: 10.1177/1947601913489020.

Identification of TET1 Partners That Control Its DNA-Demethylating Function.

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Equipe Apoptose et Progression Tumorale, Centre de Recherche en Cancérologie Nantes-Angers, INSERM U892, Nantes, France ; Département de Recherche en Cancérologie, Faculté de Médecine, Université de Nantes, Nantes, France.


Several recent reports have identified TET1 as the main enzyme modulating DNA methylation and gene transcription via hydroxylation of 5-methylcytosine. However, little is known about the protein network that controls TET1 activity. By using a new proximity ligation in situ assay, we identified MeCP2, HDAC1/6/7, EZH2, mSin3A, PCNA, and LSD1 as TET1-interacting proteins. We also discerned that TET1/PCNA acts as a demethylator of the cyclical methylation/demethylation process, the perturbation of which promotes the aberrant methylation hallmarks frequently observed in cancer cells.


DNA methylation; TET1; demethylation; glioma

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