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Front Hum Neurosci. 2013 Sep 24;7:602. doi: 10.3389/fnhum.2013.00602.

The effect of transcranial direct current stimulation: a role for cortical excitation/inhibition balance?

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1Department of Experimental Psychology, University of Oxford Oxford, Oxfordshire, UK.


Transcranial direct current stimulation (tDCS) is a promising tool for cognitive enhancement and neurorehabilitation in clinical disorders in both cognitive and clinical domains (e.g., chronic pain, tinnitus). Here we suggest the potential role of tDCS in modulating cortical excitation/inhibition (E/I) balance and thereby inducing improvements. We suggest that part of the mechanism of action of tDCS can be explained by non-invasive modulations of the E/I balance.


GABA; cognition; excitation; glutamate; inhibition; transcranial direct current stimulation (tDCS)

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