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Sci Transl Med. 2013 Sep 25;5(204):204lr4. doi: 10.1126/scitranslmed.3007442.

Response to comment on "Community-wide isoniazid preventive therapy drives drug-resistant tuberculosis: a model-based analysis".

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1
Bristol Centre for Complexity Sciences, University of Bristol, Bristol BS8 1TR, UK.

Abstract

Our modeling work suggests that isoniazid preventive therapy (IPT) can be effective in reducing drug-sensitive tuberculosis (TB) and that the risk of IPT driving resistance can be reduced by improving the detection and rapid treatment of individuals with drug-resistant disease and by limiting IPT to those in whom the intervention will have the largest benefit.

PMID:
24068734
DOI:
10.1126/scitranslmed.3007442
[Indexed for MEDLINE]
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