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Nat Rev Immunol. 2013 Oct;13(10):722-37. doi: 10.1038/nri3532.

Autophagy in infection, inflammation and immunity.

Author information

1
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, North East, Albuquerque, New Mexico 87131, USA.

Abstract

Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity. Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it provides a mechanism for the elimination of intracellular microorganisms. Autophagy controls inflammation through regulatory interactions with innate immune signalling pathways, by removing endogenous inflammasome agonists and through effects on the secretion of immune mediators. Moreover, autophagy contributes to antigen presentation and to T cell homeostasis, and it affects T cell repertoires and polarization. Thus, as we discuss in this Review, autophagy has multitiered immunological functions that influence infection, inflammation and immunity.

PMID:
24064518
PMCID:
PMC5340150
DOI:
10.1038/nri3532
[Indexed for MEDLINE]
Free PMC Article
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