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J Pediatr. 2014 Jan;164(1):186-8. doi: 10.1016/j.jpeds.2013.07.050. Epub 2013 Sep 21.

Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease.

Author information

1
Steatohepatitis Center, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address: stavra.xanthakos@cchmc.org.
2
Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
3
Department of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
4
Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
5
Steatohepatitis Center, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Abstract

Management of pediatric chronic liver disease is limited by lack of validated noninvasive biomarkers of histologic severity. We demonstrate that magnetic resonance elastography is feasible and accurate in detecting significant hepatic fibrosis in a case series of 35 children with chronic liver disease, including severely obese children.

KEYWORDS:

ARFI; AUROC; Acoustic radiation force imaging; Area under the receiver operating characteristic curve; BMI; Body mass index; MRE; Magnetic resonance elastography; NAFLD; NASH; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; ROI; Region of interest; TE; Transient elastography; US; Ultrasound

PMID:
24064151
PMCID:
PMC3872246
DOI:
10.1016/j.jpeds.2013.07.050
[Indexed for MEDLINE]
Free PMC Article

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