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Nanomedicine (Lond). 2014;9(8):1209-22. doi: 10.2217/nnm.13.84. Epub 2013 Sep 24.

Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells.

Author information

1
Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Mail: BCM 360, One Baylor Plaza, Houston, TX 77030, USA and Department of Diagnostic Imaging, The Fourth Hospital of Hebei Medical University/Hebei Province Tumor Hospital, 12 Jiankang Road, Shijiazhuang, Hebei Province 050011, China.

Abstract

AIM:

We report a magneto-fluorescent theranostic nanocomplex targeted to neutrophil gelatinase-associated lipocalin (NGAL) for imaging and therapy of pancreatic cancer.

MATERIALS & METHODS:

Gold nanoshells resonant at 810 nm were encapsulated in silica epilayers doped with iron oxide and the near-infrared (NIR) dye indocyanine green, resulting in theranostic gold nanoshells (TGNS), which were subsequently conjugated with antibodies targeting NGAL in AsPC-1-derived xenografts in nude mice.

RESULTS:

Anti-NGAL-conjugated TGNS specifically targeted pancreatic cancer cells in vitro and in vivo providing contrast for both NIR fluorescence and T2-weighted MRI with higher tumor contrast than can be obtained using long-circulating, but nontargeted, PEGylated nanoparticles. The nanocomplexes also enabled highly specific cancer cell death via NIR photothermal therapy in vitro.

CONCLUSION:

TGNS with embedded NIR and magnetic resonance contrasts can be specifically targeted to pancreatic cancer cells with expression of early disease marker NGAL, and enable molecularly targeted imaging and photothermal therapy.

KEYWORDS:

MRI; nanoshells; noninvasive imaging; optical imaging; pancreatic cancer; photothermal

PMID:
24063415
PMCID:
PMC4051872
DOI:
10.2217/nnm.13.84
[Indexed for MEDLINE]
Free PMC Article
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