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Biotechnol Lett. 2014 Feb;36(2):201-9. doi: 10.1007/s10529-013-1349-5. Epub 2013 Sep 24.

Low temperature cell pausing: an alternative short-term preservation method for use in cell therapies including stem cell applications.

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Department of Chemical Engineering, Centre for Biological Engineering, Loughborough University, LE11 3TU, Leicestershire, UK.


Encouraging advances in cell therapies have produced a requirement for an effective short-term cell preservation method, enabling time for quality assurance testing and transport to their clinical destination. Low temperature pausing of cells offers many advantages over cryopreservation, including the ability to store cells at scale, reduced cost and a simplified procedure with increased reliability. This review will focus on the importance of developing a short-term cell preservation platform as well highlighting the major successes of cell pausing and the key challenges which need addressing, to enable application of the process to therapeutically relevant cells.

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