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Clin Appl Thromb Hemost. 2015 Mar;21(2):166-71. doi: 10.1177/1076029613503398. Epub 2013 Sep 19.

Neutrophil-lymphocyte ratio may predict left atrial thrombus in patients with nonvalvular atrial fibrillation.

Author information

1
Department of Cardiology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
2
Department of Cardiology, Etimesgut Military Hospital, Ankara, Turkey.
3
Department of Cardiology, Gulhane Medical Faculty, Ankara, Turkey drsevketb@gmail.com.

Abstract

OBJECTIVE:

Neutrophil-lymphocyte ratio (NLR) has been associated with poor outcomes in patients with cardiovascular diseases. We aimed to compare NLRs among patients with nonvalvular atrial fibrillation (AF) with or without left atrial (LA) thrombus.

METHODS:

A total of 309 (70.1 ± 9.8 years, 49% male) patients with nonvalvular AF have undergone transoesophageal echocardiography (TEE) to assess the presence of LA thrombus. Baseline NLR was measured by dividing neutrophil count to lymphocyte count.

RESULTS:

Left atrial thrombus was detected in 32 (10.3%) of 309 patients. Mean NLR (2.2 ± 1.0 vs 2.7 ± 1.1, P = .026) was significantly higher among patients with LA thrombus compared to patients without LA thrombus. On multivariate analysis, NLR (odds ratio 1.59, 95% confidence interval 0.87-4.18; P < .02) was an independent risk factor for the presence of LA thrombus in patients with nonvalvular AF.

CONCLUSION:

Neutrophil-lymphocyte ratio, an emerging marker of inflammation, was independently associated with the presence of LA thrombus in patients with nonvalvular AF.

KEYWORDS:

atrial fibrillation; inflammation; left atrial thrombus; neutrophil–lymphocyte ratio

PMID:
24057399
DOI:
10.1177/1076029613503398
[Indexed for MEDLINE]
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