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Nanoscale. 2013 Nov 7;5(21):10141-54. doi: 10.1039/c3nr04015a. Epub 2013 Sep 13.

Point-of-care nucleic acid detection using nanotechnology.

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1
Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York, USA. dan.luo@cornell.edu.

Abstract

Recent developments in nanotechnology have led to significant advancements in point-of-care (POC) nucleic acid detection. The ability to sense DNA and RNA in a portable format leads to important applications for a range of settings, from on-site detection in the field to bedside diagnostics, in both developing and developed countries. We review recent innovations in three key process components for nucleic acid detection: sample preparation, target amplification, and read-out modalities. We discuss how the advancements realized by nanotechnology are making POC nucleic acid detection increasingly applicable for decentralized and accessible testing, in particular for the developing world.

PMID:
24057263
DOI:
10.1039/c3nr04015a
[Indexed for MEDLINE]
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